Dr. Bertus Beaumont

TU Delft

Bionanomachine Evolution and Nanoecology
a story on real-time modular evolution in the bacterial flagellar motor and the nanoscopic anatomy of a bacteriophage attack

Life as we know it relies on complexes of interacting proteins that perform vital functions in the cell. Although comparative analysis shows that the origin and innovation of protein complexes involved modular integration of foreign subunits, experimental evidence of the capacity of evolution to achieve is lacking. I will present results from an evolution experiment that captured the integration of incompatible protein subunits into an existing complex. We replaced genes that encode an essential part of the bacterial flagellar motor—a nanoscopic rotary motor that powers bacterial swimming—with related genes that encode similar subunits in different species. The data reveal a remarkable combinatorial potential and show that evolution is able to overcome interaction conflicts at and beyond the compatibility horizon along parallel, step-wise mutational trajectories. Remarkably, bacteria that evolved compatibility with a foreign part often remain backward compatible with the original component. I will also discuss results from an ongoing project that is revealing the nanoscopic behavioral ecology of bacterial viruses as they select and kill their targets.

Kim van Adrichem

Machine Learning for Inorganic-Organic Hybrid Materials


Teun Zijp

Revealing Spectral Inhomogeneity in Molecular Nanotubes

Alberto Carta

Alberto Carta

Simulation of excitonic transport in self-assembled nanofibers

Amara Zahid

Amara Zahid

Simulating evolutionary dynamics of seed evolvable systems of peptide- nucleotide self assembling molecular self replicators


Vincent Goossens

Graphene growth by chemical vapour depositions on copper and transfer on sapphire


Jack Mayo

Developing Machine Learning algorithms for predicting molecular structure-function relationship in molecular tunneling junctions


Miina Leiviskä

Simulating Coulomb-correlation in doped organic thermoelectric materials


Sameer Rodrigues

Wet adhesives inspired by marine animals


Panagiotis Koutsogiannis

Structural investigation of hybrid nanoparticle thin-films prepared by spark ablation deposition technique


Evgenios Stylianidis

Inks of PbS QDs with thiol-based ligands and their electronic properties in thin films


Yahia Mostafa

H-atom attachment as a novel tool for mass spectrometry


Cristhian Sumba

Excited-state dynamics of molecular photo-switches